Liver aspartate aminotransferase activity as a power function of body weight.

Abstract

Total liver enzyme activity (E) for aspartate aminotransferase (ASAT; EC 2.6.1.1) per gram body weight (W) decreases in six species as body weight increases from mice to cattle according to the equation E/W 0.85 = c, where c is a constant. The 0.85 power of body weight thereby provides a reference standard for the direct arithmetic comparison of liver ASAT activities in six species with different body weights. The use of W 0.85 should provide a tool in clinical studies in which data from experimental animals must be related to humans, e.g., in establishing the relationship between drug dosage (or toxicity) and body weight.

• Authors: N J Pappas Jr, A R Qureshi
• Journal: Biochemical medicine and metabolic biology (Biochem Med Metab Biol) Vol. 39 Issue 1 Pg. 121-5 (Feb 1988) ISSN: 0885-4505 [Print] United States
• PMID: 3355709 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Aspartate Aminotransferases

Topics

• Adult
• Animals
• Aspartate Aminotransferases (metabolism)
• Body Weight
• Cattle
• Dogs
• Female
• Humans
• Liver (enzymology)
• Male
• Mice
• Rabbits
• Rats
• Species Specificity