Abstract |
Para-aminohippuric acid (PAHA, 0.1 mg/min/kg of body weight) was infused IV into 2 mares, followed by concurrent IV infusion of PAHA and probenecid (0.075, 0.15, 0.25, or 0.35 mg of probenecid/min/kg). Probenecid infusion reduced the clearance of PAHA at serum probenecid concentrations greater than 55 micrograms/ml. At 12-hour intervals, probenecid (in 5 repeated doses - 50, 75, 100, or 200 mg/kg) was administered by gavage to 2 mares. Mean serum probenecid concentration was greater than 55 micrograms/ml for all dosages. At dosages less than 200 mg/kg, accumulation of probenecid in the serum was minimal from the 1st to the 5th dose. At a dosage of 200 mg/kg, probenecid accumulated in the serum from the 1st to the 5th dose. Intragastric administration of 5 doses of probenecid (75 mg/kg) at 12-hour intervals to 6 mares reduced the clearance of PAHA by 50%. Bioavailability of probenecid was 117 and 102% for 2 mares after a single intragastric dose, compared with a single IV dose.
|
Authors | R Gronwall, M P Brown |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 49
Issue 2
Pg. 250-3
(Feb 1988)
ISSN: 0002-9645 [Print] United States |
PMID | 3348534
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Aminohippuric Acids
- Probenecid
- p-Aminohippuric Acid
|
Topics |
- Administration, Oral
- Aminohippuric Acids
(pharmacokinetics)
- Animals
- Biological Availability
- Female
- Horses
(metabolism)
- Infusions, Intravenous
- Mathematics
- Probenecid
(administration & dosage, pharmacokinetics, pharmacology)
- Software
- p-Aminohippuric Acid
(administration & dosage, pharmacokinetics)
|