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Probenecid infusion in mares: effect on para-aminohippuric acid clearance.

Abstract
Para-aminohippuric acid (PAHA, 0.1 mg/min/kg of body weight) was infused IV into 2 mares, followed by concurrent IV infusion of PAHA and probenecid (0.075, 0.15, 0.25, or 0.35 mg of probenecid/min/kg). Probenecid infusion reduced the clearance of PAHA at serum probenecid concentrations greater than 55 micrograms/ml. At 12-hour intervals, probenecid (in 5 repeated doses - 50, 75, 100, or 200 mg/kg) was administered by gavage to 2 mares. Mean serum probenecid concentration was greater than 55 micrograms/ml for all dosages. At dosages less than 200 mg/kg, accumulation of probenecid in the serum was minimal from the 1st to the 5th dose. At a dosage of 200 mg/kg, probenecid accumulated in the serum from the 1st to the 5th dose. Intragastric administration of 5 doses of probenecid (75 mg/kg) at 12-hour intervals to 6 mares reduced the clearance of PAHA by 50%. Bioavailability of probenecid was 117 and 102% for 2 mares after a single intragastric dose, compared with a single IV dose.
AuthorsR Gronwall, M P Brown
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 49 Issue 2 Pg. 250-3 (Feb 1988) ISSN: 0002-9645 [Print] United States
PMID3348534 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminohippuric Acids
  • Probenecid
  • p-Aminohippuric Acid
Topics
  • Administration, Oral
  • Aminohippuric Acids (pharmacokinetics)
  • Animals
  • Biological Availability
  • Female
  • Horses (metabolism)
  • Infusions, Intravenous
  • Mathematics
  • Probenecid (administration & dosage, pharmacokinetics, pharmacology)
  • Software
  • p-Aminohippuric Acid (administration & dosage, pharmacokinetics)

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