Childhood hepatic mesenchymoma: successful treatment with surgery and multiple-agent chemotherapy.

Abstract

Malignant undifferentiated sarcoma (mesenchymoma) of the liver is a rare tumor of childhood, with fewer than 100 cases reported in the literature. The overall prognosis for patients with this malignancy is poor. In this report, two children with hepatic mesenchymoma underwent surgical excision followed by 2 years of adjuvant chemotherapy. Rotating cycles of cisplatinum, vincristine/doxorubicin, vincristine/cyclophosphamide, and vincristine/actinomycin D were given with minimal toxicity. Both patients are alive, with no evidence of disease at least 5 years from diagnosis. Previous reports of treatment are reviewed.

• Authors: R Ware, H S Friedman, H C Filston, S Chaffee, J Kurtzberg, T R Kinney, J M Falletta
• Journal: Medical and pediatric oncology (Med Pediatr Oncol) Vol. 16 Issue 1 Pg. 62-5 ( 1988) ISSN: 0098-1532 [Print] United States
• PMID: 3340065 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Cisplatin

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Female
• Humans
• Liver Neoplasms (drug therapy, surgery, therapy)
• Male
• Mesenchymoma (drug therapy, surgery, therapy)
• Vincristine (administration & dosage)