Natural interferon alfa for treatment of condylomata acuminata.

Abstract

The activity of natural (leukocyte) interferon alfa in the treatment of condylomata acuminata was assessed in a randomized, double-blind, placebo-controlled, multicenter trial. Interferon alfa (Alferon N Injection) or placebo was injected into lesions twice weekly for up to eight weeks. Eighty-six patients were given interferon alfa, and 72 were given placebo. Eighty-six percent of interferon alfa-treated patients and 89% of placebo-treated patients had received previous therapy for condylomata acuminata. Side effects, usually flulike symptoms, occurred briefly after the injections; if present, they disappeared before the end of the third week of therapy. Treatment completely eliminated warts in 62% of interferon alfa-treated patients compared with only 21% of placebo-treated patients. Natural interferon alfa given intralesionally is an effective and safe treatment even in patients with recurrent or recalcitrant genital warts.

• Authors: A E Friedman-Kien, L J Eron, M Conant, W Growdon, H Badiak, P W Bradstreet, D Fedorczyk, J R Trout, T F Plasse
• Journal: JAMA (JAMA) 1988 Jan 22-29 Vol. 259 Issue 4 Pg. 533-8 ISSN: 0098-7484 [Print] United States
• PMID: 3336177 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Interferon Type I

Topics

• Adult
• Condylomata Acuminata (therapy)
• Double-Blind Method
• Drug Evaluation
• Female
• Fever (etiology)
• Genital Neoplasms, Female (therapy)
• Genital Neoplasms, Male (therapy)
• Humans
• Influenza, Human (etiology)
• Interferon Type I (adverse effects, therapeutic use)
• Leukocyte Count
• Male
• Random Allocation