Nasal pharmacodynamics of brompheniramine in perennial rhinitis.

Abstract

This study evaluated the relationship between brompheniramine maleate and changes in nasal reactivity. Ten subjects with moderate-to-severe perennial rhinitis took brompheniramine for seven days using either a standard formulation or sustained-release preparation. Nasal aerodynamics and response to histamine were assessed at the end of the week. Despite varying doses of brompheniramine maleate (12 to 32 mg/d), there was no significant difference in nasal reactivity to histamine or in changes of nasal airflow, indicating that low doses of brompheniramine are highly effective in blocking histamine, receptors in the nasal mucosa.

• Authors: J W Georgitis, D Shen
• Journal: Archives of otolaryngology--head & neck surgery (Arch Otolaryngol Head Neck Surg) Vol. 114 Issue 1 Pg. 63-7 (Jan 1988) ISSN: 0886-4470 [Print] United States
• PMID: 3334821 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Delayed-Action Preparations
• Pyridines
• Histamine
• Brompheniramine

Topics

• Adolescent
• Adult
• Airway Resistance (drug effects)
• Brompheniramine (administration & dosage, therapeutic use)
• Delayed-Action Preparations
• Dose-Response Relationship, Drug
• Female
• Histamine
• Humans
• Male
• Nasal Cavity (physiopathology)
• Pyridines (therapeutic use)
• Rhinitis, Allergic, Perennial (diagnosis, drug therapy, physiopathology)