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Once-nightly treatment with pirenzepine or cimetidine for peptic ulcers: a multicentre, randomised, double blind, controlled study.

Abstract
Sixty-nine patients with symptomatic and endoscopically diagnosed gastric or duodenal ulcers received treatment with either pirenzepine 100 mg or cimetidine 800 mg one hour before bedtime in a prospective randomised, double blind study. Fifty-five patients completed the six weeks treatment period of whom 13/15 (87%) gastric ulcers and 13/16 (81%) duodenal ulcers, healed with pirenzepine compared to 8/11 (73%) gastric ulcers and 10/13 (77%) duodenal ulcers treated with cimetidine for the same period. The differences in healing rates between pirenzepine and cimetidine were not statistically significant. Pirenzepine 100 mg administered at night is therefore an effective treatment for gastric and duodenal ulcers.
AuthorsD P Edge, P Brown, K Luey, N H Stace
JournalThe New Zealand medical journal (N Z Med J) Vol. 100 Issue 836 Pg. 705-7 (Nov 25 1987) ISSN: 0028-8446 [Print] New Zealand
PMID3330601 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Pirenzepine
  • Cimetidine
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cimetidine (administration & dosage, adverse effects, therapeutic use)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peptic Ulcer (drug therapy)
  • Pirenzepine (administration & dosage, adverse effects, therapeutic use)
  • Prospective Studies
  • Random Allocation

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