The effect of TP-3 (Arg-Lys-Asp), TP-4 (Arg-Lys-Asp-Val), and TP-5 on the metastatic capacity of intravenously injected Lewis lung tumor cells.

Abstract

The oligopeptides Arg-Lys-Asp (TP-3), Arg-Lys-Asp-Val (TP-4), and Arg-Lys-Asp-Val-Tyr (TP-5) considered as the active short fragments of thymopoietin were administered (lo mg/kg) to C57B1 mice 24 hours before the intravenous inoculation of Lewis lung tumor (LLT) cells. A substantial decrease in lung metastasis number was observed as a result of treatment with all of the three oligopeptides. TP-3, TP-4, and TP-5 treatment decreased the immunosuppressive activity of Cyclophosphamid (240 mg/kg) given 96 hours before the inoculation of LLT cells. After thymectomy, performed eight days before the LLT inoculation, only TP-3 treatment resulted in the decrease of Cyclophosphamid immunotoxicity. A stimulating effect of TP-3 on T helper cell activity is assumed. The oligopeptides TP-3, TP-4, and TP-5 are recommended for clinical trial in case of malignant tumors and immunodeficiency.

• Authors: B Szende, K Lapis, K Pal, L Sipos, L Denes, L Kisfaludy
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 9 Issue 1 Pg. 19-24 ( 1987) ISSN: 0892-3973 [Print] England
• PMID: 3330095 (Publication Type: Journal Article)

Chemical References

• Peptide Fragments
• Thymopoietins
• Thymus Hormones
• Cyclophosphamide
• Thymopentin

Topics

• Animals
• Cyclophosphamide (pharmacology)
• Immunosuppression Therapy
• Injections, Intravenous
• Lung Neoplasms (prevention & control, secondary)
• Male
• Mice
• Mice, Inbred Strains
• Neoplasm Metastasis (prevention & control)
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Peptide Fragments (therapeutic use)
• Thymectomy
• Thymopentin
• Thymopoietins (analogs & derivatives, therapeutic use)
• Thymus Hormones (therapeutic use)