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A prospective multicenter study of insulin and glucagon infusion therapy in acute alcoholic hepatitis.

Abstract
A randomized, single-blind controlled multicenter study of insulin and glucagon infusion was carried out in 66 patients with acute alcoholic hepatitis. Thirty-three patients were treated with insulin 10 U and glucagon 1 mg in 500 ml 5% glucose in water via a peripheral vein for 2-6 h three times every day for 3 weeks. Patients in the control group received 5% glucose in an identical fashion. Fourteen control patients and five treated patients died from liver failure during the study (P less than 0.02). Clinical features of liver disease on entry into the study were similar in the two groups, but the total serum bilirubin, aspartate aminotransferase, gamma-glutamyltranspeptidase activities and prothrombin time significantly improved in the treated patients (P less than 0.05). Insulin and glucagon infusion appears to be a promising treatment of acute alcoholic hepatitis.
AuthorsJ Fehér, A Cornides, A Romány, M Kárteszi, L Szalay, A Gógl, J Picazo
JournalJournal of hepatology (J Hepatol) Vol. 5 Issue 2 Pg. 224-31 (Oct 1987) ISSN: 0168-8278 [Print] Netherlands
PMID3320181 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Insulin
  • Glucagon
Topics
  • Adult
  • Aged
  • Female
  • Glucagon (administration & dosage, therapeutic use)
  • Hepatitis, Alcoholic (drug therapy, mortality, pathology)
  • Humans
  • Insulin (administration & dosage, therapeutic use)
  • Liver Function Tests
  • Male
  • Middle Aged
  • Multi-Institutional Systems
  • Prospective Studies

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