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Nabumetone: a single-center three-week comparison with placebo in the treatment of rheumatoid arthritis.

Abstract
Forty-six patients with definite or classical rheumatoid arthritis were entered into a three-week, double-blind, randomized, parallel study of nabumetone, 1,000 mg at bedtime, compared with placebo. Fifteen nabumetone-treated and 12 placebo-treated patients were evaluated for efficacy variables including physician's opinion of rheumatoid arthritis activity, patient's opinion of rheumatoid arthritis activity, articular index, morning stiffness, 50-foot walking time, grip strength, and acetaminophen consumption. Between-group analysis of improvement over baseline was significantly (p less than 0.05) greater for nabumetone-treated patients for six of the seven variables. Nabumetone was significantly favored over placebo in three global evaluations and significantly more placebo-treated (75 percent) than nabumetone-treated (20 percent) patients withdrew from the study due to an unsatisfactory therapeutic response. Of the 38 patients receiving the study medication, 22 percent of nabumetone-treated and 5 percent of placebo-treated patients reported adverse experiences either related to treatment or for which the relationship to treatment was unknown. No patients were withdrawn from the study as a result of these experiences and no long-term sequelae or clinically significant laboratory abnormalities were reported.
AuthorsR A Turner Jr, D A Brindley, F N Mitchell
JournalThe American journal of medicine (Am J Med) Vol. 83 Issue 4B Pg. 36-9 (Oct 30 1987) ISSN: 0002-9343 [Print] UNITED STATES
PMID3318426 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Butanones
  • Placebos
  • nabumetone
Topics
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
  • Arthritis, Rheumatoid (drug therapy)
  • Butanones (adverse effects, therapeutic use)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Middle Aged
  • Placebos
  • Random Allocation

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