[A new peptide activator of reparative tissue regeneration].

Abstract

Synthetic analog of leucine enkephalin--hexapeptide dalargin was shown to stimulate healing of skin wounds in rats, dogs and mini-pigs at local and parenteral administration in doses of 0.1-100 micrograms/kg. Acceleration of proliferation with an increase of fibroblast mitoses, earlier and active growth of vascular elements, rapid maturation of granulation tissue and accelerated epithelialization were observed.

• Authors: O B Il'inskiĭ, S E Spevak, A B Shekhter, A I Solov'eva, M I Titov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1987 Jul-Aug Vol. 50 Issue 4 Pg. 64-6 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Novyĭ peptidnyĭ aktivator reparativnoĭ regeneratsii tkaneĭ.
• PMID: 3311802 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Ointments
• Enkephalin, Leucine
• Enkephalin, Leucine-2-Alanine
• enkephalin-Leu, Ala(2)-Arg(6)-

Topics

• Animals
• Dogs
• Enkephalin, Leucine (administration & dosage, analogs & derivatives, pharmacology)
• Enkephalin, Leucine-2-Alanine (analogs & derivatives)
• Female
• Injections, Intramuscular
• Injections, Intraperitoneal
• Male
• Ointments
• Rats
• Rats, Inbred Strains
• Skin (drug effects, injuries)
• Stimulation, Chemical
• Swine
• Swine, Miniature
• Time Factors
• Wound Healing (drug effects)