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Herpes gestationis factor reacts with the amniotic epithelial basement membrane.

Abstract
Sera from five patients with clinically and immunopathologically proven herpes gestationis were studied by complement fixing immunofluorescence and complement fixing immuno-electron microscopy using specimens of skin, amniochorion and placenta. The results demonstrated that the complement fixation antibody (herpes gestationis factor) could bind to the basement membrane zone of skin, amnion and chorion laeve but not to that of the placental syncytiotrophoblast. These data suggest that the herpes gestationis factor may be induced by the basement membrane zone antigens of extra-villous cytotrophoblasts.
AuthorsJ P Ortonne, B L Hsi, P Verrando, F Bernerd, G Pautrat, A Pisani, C J Yeh
JournalThe British journal of dermatology (Br J Dermatol) Vol. 117 Issue 2 Pg. 147-54 (Aug 1987) ISSN: 0007-0963 [Print] England
PMID3307892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
Topics
  • Amnion (immunology, ultrastructure)
  • Antibodies (immunology)
  • Basement Membrane (immunology, ultrastructure)
  • Complement Fixation Tests
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Microscopy, Electron
  • Pemphigoid Gestationis (immunology)
  • Placenta (immunology, ultrastructure)
  • Pregnancy
  • Pregnancy Complications (immunology)
  • Skin Diseases, Vesiculobullous (immunology)

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