Piperacillin and a combination of clindamycin and gentamicin for the treatment of hospital and community acquired acute pelvic infections including pelvic abscess.

Abstract

Therapy for acute polymicrobial pelvic infections is empiric and must include predictable anaerobic coverage. Single agent therapy, if effective, is advantageous for the patient, nurses, pharmacy and hospital. Piperacillin sodium was compared with a combination of clindamycin and gentamicin as therapy for 63 female patients who were hospitalized with acute pelvic infections including pelvic abscess complicating community acquired salpingitis. Over-all clinical efficacy with piperacillin was 96.8 per cent and 90.3 per cent for clindamycin and gentamicin. Fewer bacteria demonstrated in vitro resistance to piperacillin (p = 0.008) and the cost of treatment for these infections was significantly less with piperacillin (p less than 0.05). Serious adverse reactions were not observed with either regimen. Piperacillin provides effective, cost-efficient therapy for women with acute polymicrobial pelvic infections.

• Authors: D L Hemsell, P G Hemsell, M C Heard, B J Nobles
• Journal: Surgery, gynecology & obstetrics (Surg Gynecol Obstet) Vol. 165 Issue 3 Pg. 223-9 (Sep 1987) ISSN: 0039-6087 [Print] United States
• PMID: 3306994 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gentamicins
• Clindamycin
• Piperacillin

Topics

• Abscess (drug therapy, economics)
• Adult
• Bacterial Infections (drug therapy, economics)
• Clindamycin (therapeutic use)
• Clinical Trials as Topic
• Costs and Cost Analysis
• Cross Infection (drug therapy, economics)
• Drug Therapy, Combination
• Female
• Gentamicins (therapeutic use)
• Humans
• Pelvic Inflammatory Disease (drug therapy, economics)
• Piperacillin (therapeutic use)
• Random Allocation
• Salpingitis (drug therapy)