Abstract |
Sixty-two patients with mycologically confirmed tinea pedis received two different treatment regimens of ketoconazole 2% cream on a randomized double-blind basis for 1 month with weekly evaluations. A 4-week posttreatment follow-up permitted an assessment of recurrence or improvement. After 1 month of treatment, 90% of the patients treated once daily responded clinically, in comparison with 83% of those treated twice daily. The cure rate was 63% for the once-daily and 60% for the twice-daily group. This rate substantially improved at follow-up (77% and 73%, respectively). One patient from each group discontinued therapy for an adverse reaction. On the basis of both clinical and mycologic assessments, topical treatment with ketoconazole 2% cream was effective as a once-daily therapy.
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Authors | D Greer, H W Jolly |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 17
Issue 1
Pg. 53-6
(Jul 1987)
ISSN: 0190-9622 [Print] United States |
PMID | 3301923
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Clinical Trials as Topic
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Ketoconazole
(administration & dosage, therapeutic use)
- Male
- Ointments
- Random Allocation
- Tinea Pedis
(drug therapy)
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