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Comparative trial of a two-dosage schedule of ketoconazole 2% cream for the treatment of tinea pedis.

Abstract
Sixty-two patients with mycologically confirmed tinea pedis received two different treatment regimens of ketoconazole 2% cream on a randomized double-blind basis for 1 month with weekly evaluations. A 4-week posttreatment follow-up permitted an assessment of recurrence or improvement. After 1 month of treatment, 90% of the patients treated once daily responded clinically, in comparison with 83% of those treated twice daily. The cure rate was 63% for the once-daily and 60% for the twice-daily group. This rate substantially improved at follow-up (77% and 73%, respectively). One patient from each group discontinued therapy for an adverse reaction. On the basis of both clinical and mycologic assessments, topical treatment with ketoconazole 2% cream was effective as a once-daily therapy.
AuthorsD Greer, H W Jolly
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 17 Issue 1 Pg. 53-6 (Jul 1987) ISSN: 0190-9622 [Print] United States
PMID3301923 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Ointments
  • Ketoconazole
Topics
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Ketoconazole (administration & dosage, therapeutic use)
  • Male
  • Ointments
  • Random Allocation
  • Tinea Pedis (drug therapy)

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