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Cefotetan in the treatment of serious intra-abdominal sepsis: a controlled clinical trial.

Abstract
Cefotetan has been compared with two regimens of combination antibiotic therapy in the treatment of peritonitis and serious intra-abdominal sepsis. One hundred predominantly elderly patients (median age 66 years) were entered into a prospective randomized surgical trial. Sixty-two per cent had peritonitis. There were seven non-septic deaths. Side-effects were similar in each group and generally of a minor, self limiting nature. Haematological and biochemical factors were closely monitored, and though there were increases in the prothrombin time, there was no statistical difference between cefotetan and comparators. Cefotetan is as effective as combination therapy in the treatment of surgical patients with serious intra-abdominal sepsis.
AuthorsS D Scott, S J Karran
JournalInternational journal of clinical pharmacology research (Int J Clin Pharmacol Res) Vol. 7 Issue 3 Pg. 229-31 ( 1987) ISSN: 0251-1649 [Print] Switzerland
PMID3298087 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Cephamycins
  • Cefotetan
Topics
  • Abdomen
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Infections (drug therapy, surgery)
  • Cefotetan
  • Cephamycins (adverse effects, therapeutic use)
  • Clinical Trials as Topic
  • Humans
  • Liver Function Tests
  • Middle Aged
  • Peritonitis (drug therapy, surgery)
  • Prospective Studies
  • Prothrombin Time
  • Random Allocation
  • Recurrence
  • Surgical Wound Infection (etiology)

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