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Plasma exchange and immunosuppression in rapidly progressive glomerulonephritis: a controlled, multi-center study.

Abstract
In a randomized study of 26 patients with histologically confirmed rapidly progressive crescentic glomerulonephritis, 12 patients were treated with immunosuppressants alone (corticosteroids, cyclophosphamide and azathioprine) while the other 14 patients received not only the identical immunosuppressive treatment but also plasma exchange therapy for four weeks. No statistically significant difference was found between the two groups. After 8 weeks, 73% and 69% of the patients in each respective group showed recompensation of renal function; serum creatinine fell from initially 7.0 and 6.2 mg/dl mean to 2.7 and 2.3 mg/dl mean, and under continued immunosuppression did not rise in the following months. Thus, in non-autoantibody induced rapidly progressive glomerulonephritis, kidney function could be improved substantially by immunosuppressive therapy, but an advantage of supplementary plasma exchange could not be shown.
AuthorsW M Glöckner, H G Sieberth, H E Wichmann, E Backes, R Bambauer, W H Boesken, A Bohle, A Daul, N Graben, F Keller
JournalClinical nephrology (Clin Nephrol) Vol. 29 Issue 1 Pg. 1-8 (Jan 1988) ISSN: 0301-0430 [Print] Germany
PMID3289804 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Immunosuppressive Agents
  • Cyclophosphamide
  • Azathioprine
  • Methylprednisolone
Topics
  • Adult
  • Azathioprine (therapeutic use)
  • Clinical Trials as Topic
  • Cyclophosphamide (therapeutic use)
  • Female
  • Glomerulonephritis (therapy)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Methylprednisolone (therapeutic use)
  • Middle Aged
  • Plasma Exchange
  • Plasmapheresis
  • Prospective Studies
  • Random Allocation
  • Time Factors

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