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Semantics and the chemotherapy of Hodgkin's disease--resistance is not relapse: alternative chemotherapy lacks effectiveness for disease not totally responsive to initial MOPP treatment.

Abstract
Patients with advanced Hodgkin's disease not achieving a complete remission with initial MOPP therapy are significantly less responsive to adriamycin and nitrosourea-containing regimens than patients with relapsing disease following a complete remission with MOPP. Hodgkin's disease not responding completely to initial four-drug treatment represents resistant disease which, in most instances, may not be cured with existing alternative chemotherapy. These patients should receive innovative treatment.
AuthorsM Coleman, R J Friedlander Jr
JournalCancer investigation (Cancer Invest) Vol. 6 Issue 2 Pg. 237-9 ( 1988) ISSN: 0735-7907 [Print] England
PMID3288299 (Publication Type: Journal Article, Review)
Chemical References
  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Prednisone
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Drug Administration Schedule
  • Drug Resistance
  • Hodgkin Disease (drug therapy)
  • Humans
  • Mechlorethamine (administration & dosage)
  • Prednisone (administration & dosage)
  • Procarbazine (administration & dosage)
  • Recurrence
  • Remission Induction
  • Vincristine (administration & dosage)

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