Prevention of recurrent urinary tract infections in premenopausal women by post-coital administration of cinoxacin.

Abstract

A total of 21 sexually active premenopausal women, prone to recurrent urinary tract infections but who otherwise were healthy, underwent post-coital prophylaxis consisting of bladder voiding and a single 250 mg. tablet of cinoxacin. While 94 urinary tract infections occurred during a mean of 7.5 months before treatment, only 8 occurred during a mean of 12.5 months after prophylaxis. This difference was statistically highly significant. A mean of 106 cinoxacin tablets per patient were administered during post-coital prophylaxis. Cinoxacin represents an additional valuable and effective antibacterial in post-coital prophylaxis of recurrent urinary tract infection in otherwise healthy premenopausal women, although it is slightly less effective than cotrimoxazole or nitrofurantoin. Effective post-coital prophylaxis requires the use of much smaller quantities of antibacterial agents than the daily use of a single tablet and in women with a high incidence of recurrent urinary tract infections it is superior to intermittent self-administered antibacterial therapy.

• Authors: A Pfau, T G Sacks, M Shapiro
• Journal: The Journal of urology (J Urol) Vol. 139 Issue 6 Pg. 1250-2 (Jun 1988) ISSN: 0022-5347 [Print] United States
• PMID: 3286892 (Publication Type: Journal Article)

Chemical References

• Pyridazines
• Cinoxacin

Topics

• Adult
• Cinoxacin (administration & dosage, therapeutic use)
• Coitus
• Drug Administration Schedule
• Escherichia coli Infections (prevention & control)
• Female
• Humans
• Pyridazines (therapeutic use)
• Recurrence
• Urinary Tract Infections (prevention & control)