Comparison of efficacy and tolerance of different oral doses of torasemide and furosemide in patients with advanced chronic renal failure.

Abstract

In a double-blind, randomised group comparative study the efficacy of daily oral administration of 100 mg and 200 mg torasemide (1-isopropyl-3-([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) were compared with that of 250 mg furosemide over 2 weeks in patients with advanced chronic renal failure, who had been pretreated with a maintenance therapy of 500 mg furosemide per day. Of the 19 patients 7 had been allocated strictly at random to 100 mg torasemide, 6 to 200 mg torasemide and 6 patients to 250 mg furosemide. The volume excretion after administration of 200 mg torasemide was significantly higher than after administration of 250 mg furosemide and non-significantly higher than after 100 mg torasemide. In comparison with baseline values under pretreatment with 500 mg furosemide there was a slight reduction of fluid and sodium excretion in the 100 mg torasemide group and a clear reduction in the 250 mg furosemide group. In contrast, in the 200 mg torasemide group excretion of fluid and sodium increased. The tolerance was good in all 3 groups.

• Authors: J Kult, W Häcker, M Glocke
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 38 Issue 1A Pg. 212-4 (Jan 1988) ISSN: 0004-4172 [Print] Germany
• PMID: 3285837 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Diuretics
• Electrolytes
• Sulfonamides
• Uric Acid
• Furosemide
• Sodium
• Creatinine
• Torsemide

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Clinical Trials as Topic
• Creatinine (urine)
• Diuretics (administration & dosage, adverse effects, therapeutic use)
• Double-Blind Method
• Electrolytes (urine)
• Female
• Furosemide (administration & dosage, adverse effects, therapeutic use)
• Humans
• Kidney Failure, Chronic (drug therapy, physiopathology)
• Male
• Middle Aged
• Random Allocation
• Sodium (urine)
• Sulfonamides (administration & dosage, adverse effects, therapeutic use)
• Torsemide
• Uric Acid (urine)