Single dose comparison of torasemide and furosemide in patients with advanced renal failure.

Abstract

In a comparative study on the fluid and electrolyte excretion of 90 patients with chronic renal failure (serum creatinine greater than or equal to 3.0 mg/dl) 100 and 200 mg torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) vs. 100 and 200 mg furosemide were administered intravenously. A long-acting salidiuretic effect was demonstrated for torasemide. Torasemide can thus be categorized as a high-ceiling, long-acting diuretic. Tolerance of both diuretics was comparable.

• Authors: K Klütsch, J Grosswendt, W Haecker
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 38 Issue 1A Pg. 200-4 (Jan 1988) ISSN: 0004-4172 [Print] Germany
• PMID: 3285834 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Chlorides
• Diuretics
• Sulfonamides
• Furosemide
• Sodium
• Creatinine
• Potassium
• Torsemide

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Chlorides (blood)
• Clinical Trials as Topic
• Creatinine (blood)
• Diuretics (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Furosemide (administration & dosage, therapeutic use)
• Heart Rate (drug effects)
• Humans
• Kidney Failure, Chronic (drug therapy)
• Male
• Middle Aged
• Potassium (blood)
• Random Allocation
• Sodium (blood)
• Sulfonamides (administration & dosage, therapeutic use)
• Torsemide