[Technical advances in demonstration of treponema-specific 19S-IgM antibodies in patients with latent or late-latent syphilis (author's transl)].

Abstract

In patients with latent or late-latent syphilis as well as neurosyphilis the demonstration of treponema-specific 19S-IgM antibodies is not regularly possible. In this publication it is shown that high IgG antibodies are the reason for a competitive IgM inhibition in the indirect immunofluorescence tests. It is demonstrated that in the above mentioned states of the infection the IgM-FTA-19S test seemed to be the method of choice to realize the existence of 19S-IgM antibodies. In sera with competitive inhibited IgM it is possible to calculate the IgM antibody activity with the aid of the socalled F factor.

• Authors: F Müller
• Journal: Immunitat und Infektion (Immun Infekt) Vol. 5 Issue 3 Pg. 109-13 (Jun 1977) Germany
• Vernacular Title: Zur Technik des Nachweises treponemenspezifischer 19S-IgM-Antikörper bei der latenten und spätlatenten Syphilis.
• PMID: 328375 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Bacterial
• Immunoglobulin G
• Immunoglobulin M

Topics

• Antibodies, Bacterial (analysis)
• Binding, Competitive
• Fluorescent Antibody Technique
• Humans
• Immunoglobulin G
• Immunoglobulin M (analysis)
• Neurosyphilis (diagnosis)
• Syphilis (immunology)
• Syphilis Serodiagnosis
• Treponema pallidum (immunology)