Regulation of H-2 class I gene expression in virally transformed and infected cells.

Abstract

Early studies of the resistance and susceptibility of mouse strains to radiation-induced leukemia virus have demonstrated the important role of altered histocompatibility (H-2) antigen expression in the effectiveness of the immune response of the host to virus-infected and transformed cells. Changes in H-2 gene expression have now been correlated with disease resistance in a variety of viral systems. The experiments discussed indicate that viruses may directly or indirectly affect H-2 antigen expression at various levels of gene expression. These investigations generate a framework for approaching a molecular understanding of viral-induced changes in H-2 gene expression.

• Authors: G D Brown, Y Choi, C Pampeno, D Meruelo
• Journal: Critical reviews in immunology (Crit Rev Immunol) Vol. 8 Issue 3 Pg. 175-215 ( 1988) ISSN: 1040-8401 [Print] United States
• PMID: 3280242 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• H-2 Antigens

Topics

• Animals
• Cell Transformation, Viral
• Gene Expression Regulation
• Genes, MHC Class I
• H-2 Antigens (genetics)
• Leukemia, Experimental (genetics, immunology)
• Mice
• Retroviridae (genetics)
• Tumor Virus Infections (genetics, immunology)