Abstract |
Bromocriptine and placebo were given to a group of 20 polycystic ovarian disease patients on a double-blind, cross-over basis. Patients were studied for three cycles: a baseline cycle without any medication, a placebo-treated cycle, and a bromocriptine-treated cycle with multiple plasma samples taken during the different phases of the menstrual cycle. The clinical response to bromocriptine was compared with that of a placebo for the following hormones: prolactin (PRL), luteinizing hormone (LH)/ follicle-stimulating hormone (FSH) ratio, testosterone, androstenedione, estradiol-17 beta (E2), estrone (E1), and progesterone. Patients were divided into two subgroups: hyperprolactinemic (basal PRL greater than 20 ng/mL) and normoprolactinemic (basal PRL less than 20 ng/mL), and the response of both subgroups to bromocriptine was compared. Prolactin, LH/FSH ratio, testosterone, and E1 showed a significant drop with bromocriptine, whereas E2 significantly increased. Two out of nine amenorrheic polycystic ovarian disease patients menstruated during bromocriptine treatment, and three patients showed evidence of ovulation.
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Authors | G H el Tabbakh, I A Loutfi, I Azab, H A Rahman, A L Southren, F A Aleem |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 71
Issue 3 Pt 1
Pg. 301-6
(Mar 1988)
ISSN: 0029-7844 [Print] United States |
PMID | 3279350
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gonadal Steroid Hormones
- Bromocriptine
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Topics |
- Adolescent
- Adult
- Amenorrhea
(complications, physiopathology)
- Bromocriptine
(adverse effects, therapeutic use)
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Gonadal Steroid Hormones
(blood)
- Humans
- Menstruation
- Ovulation
- Polycystic Ovary Syndrome
(blood, complications, drug therapy)
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