Cefoperazone versus combination antibiotic therapy of hospital-acquired pneumonia.

Abstract

Cefoperazone monotherapy was compared with combination antibiotic therapy in a randomized prospective evaluation of patients with hospital-acquired pneumonia. Cefoperazone was as effective as either clindamycin/gentamicin or cefazolin/gentamicin (cure rate: 45 of 52 cefoperazone-treated patients [87 percent], versus 44 of 61 combination-therapy patients [72 percent], p = 0.069). With the exception of hypoprothrombinemia in those patients who did not receive prophylactic vitamin K, there was no difference in the incidence of side effects. In addition, no difference was noted in the incidence of superinfections or secondary pneumonias. When antibiotic costs, administration costs, and laboratory costs were considered, cefoperazone monotherapy was the least expensive antibiotic regimen. Cefoperazone is a suitable alternative to combination antibiotic therapy for the treatment of hospital-acquired pneumonia.

• Authors: R J Mangi, T Greco, J Ryan, G Thornton, V T Andriole
• Journal: The American journal of medicine (Am J Med) Vol. 84 Issue 1 Pg. 68-74 (Jan 1988) ISSN: 0002-9343 [Print] United States
• PMID: 3276187 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Gentamicins
• Clindamycin
• Cefoperazone
• Cefazolin

Topics

• Anti-Bacterial Agents (therapeutic use)
• Cefazolin (administration & dosage)
• Cefoperazone (adverse effects, therapeutic use)
• Clindamycin (administration & dosage)
• Clinical Trials as Topic
• Costs and Cost Analysis
• Cross Infection (drug therapy)
• Drug Therapy, Combination
• Gentamicins (administration & dosage)
• Humans
• Hypoprothrombinemias (chemically induced)
• Pneumonia (drug therapy)
• Prospective Studies
• Random Allocation