A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee.

Abstract

A randomized, double-blind crossover study conducted on 55 patients showed tolmetin (Tolectin; Ethnor) (900 mg daily) to be as effective as aspirin (4 500 mg daily) in relieving the symptoms and signs of osteo-arthritis of the knee. Overall, aspirin produced significantly more side-effects, but the incidence of gastro-intestinal side-effects did not differ significantly. In almost every comparison tolmetin had the better score, but differences were not statistically significant; the only exception was the evaluation of the patients' well-being at mid-therapy, which significanlty favoured tolmetin.

• Authors: F O Müller, J A Gosling, G H Erdmann
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 51 Issue 22 Pg. 794-6 (May 28 1977) ISSN: 0256-9574 [Print] South Africa
• PMID: 327585 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Pyrroles
• Tolmetin
• Aspirin

Topics

• Aspirin (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Humans
• Knee Joint
• Osteoarthritis (drug therapy)
• Pyrroles (therapeutic use)
• Tolmetin (adverse effects, therapeutic use)