Abstract |
During 1984 to 1988, 35 patients with urinary tract infection (UTI) and 37 patients with enteric fever were treated successfully with 400 mg ofloxacin twice a day for 7 to 10 days. Clinical cure or improvement was observed in 31 of the 35 patients with UTI; 32 patients were bacteriologically assessed and eradication was achieved in all of them. Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyphi A subsequently died, due to his underlying disorder. The MIC90 of the Enterobacteriaceae including Salmonella was less than 0.12 micrograms/ml. Interestingly, beta-lactamase-producing strains of Salmonella and other Enterobacteriaceae in the present study were 28% and 29%, respectively. Ofloxacin therefore offers an effective b.i.d. dosage schedule for enteric fever and UTI due to beta-lactamase-producing bacteria.
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Authors | D Tanphaichitra, S Srimuang |
Journal | Drugs under experimental and clinical research
(Drugs Exp Clin Res)
Vol. 14
Issue 8
Pg. 529-31
( 1988)
ISSN: 0378-6501 [Print] Switzerland |
PMID | 3266853
(Publication Type: Journal Article)
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Chemical References |
- Ofloxacin
- beta-Lactamases
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Enterobacteriaceae
(drug effects, enzymology)
- Half-Life
- Humans
- Male
- Middle Aged
- Ofloxacin
(therapeutic use)
- Salmonella
(drug effects, enzymology)
- Typhoid Fever
(drug therapy)
- Urinary Tract Infections
(drug therapy)
- beta-Lactamases
(biosynthesis)
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