Maternal arterial desaturation with 15-methyl prostaglandin F2 alpha for uterine atony.

Abstract

Over a six-month period, five women with severe uterine atony and postpartum hemorrhage developed marked maternal arterial oxygen desaturation within five to ten minutes of the administration of 15-methyl prostaglandin F2 alpha. The average fall from baseline was 10.4 +/- 5.4%, to a mean arterial oxygen saturation of 88.8 +/- 5.45%. The desaturation was accompanied by acute increases, averaging 20.7 +/- 5.9%, in the intrapulmonary shunt.

• Authors: G D Hankins, G K Berryman, R T Scott Jr, D Hood
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 72 Issue 3 Pt 1 Pg. 367-70 (Sep 1988) ISSN: 0029-7844 [Print] United States
• PMID: 3261408 (Publication Type: Journal Article)

Chemical References

• Prostaglandins F, Synthetic
• Carboprost
• Oxygen

Topics

• Blood Gas Analysis
• Carboprost (adverse effects, therapeutic use)
• Female
• Humans
• Oximetry
• Oxygen (blood)
• Postpartum Hemorrhage (blood)
• Pregnancy
• Prostaglandins F, Synthetic (adverse effects)
• Time Factors
• Uterine Inertia (blood, complications, drug therapy)