Urinary excretion of aldosterone metabolite Kelly-M1 in patients with adrenal dysfunction.

Abstract

Using tetrahydroaldosterone antibody a radioimmunoassay was developed to measure substance Kelly-M1 (K-M1) in human urine. The normal values were lower than observed by Kelly et al. who discovered the catabolite after giving large doses of exogenous aldosterone. While in essential hypertension the excretion of K-M1 was predominantly within the normal range, elevated values were found in most cases of 21-hydroxylase deficiency, both the simple virilizing and salt losing form, primary aldosteronism, renal hypertension and cystinosis. Our findings suggest that K-M1 may be formed from 21-deoxyaldosterone and/or by microbial intervention from aldosterone or its metabolites.

• Authors: S Lewicka, P Vecsei, K Bige, T Fisher, J Winter, S Abdelhamid, U Heinrich, V D Bokkenheuser
• Journal: Journal of steroid biochemistry (J Steroid Biochem) Vol. 29 Issue 3 Pg. 333-9 (Mar 1988) ISSN: 0022-4731 [Print] England
• PMID: 3258645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Pregnanes
• 21-deoxyaldosterone
• Aldosterone
• 11,18-18,20-diepoxypregnan-3-ol

Topics

• Adrenal Gland Diseases (urine)
• Adrenal Gland Neoplasms (urine)
• Adrenal Hyperplasia, Congenital
• Aldosterone (analogs & derivatives, urine)
• Cystinosis (urine)
• Humans
• Hyperaldosteronism (urine)
• Hypertension (urine)
• Hypertension, Renal (urine)
• Pregnanes (urine)
• Radioimmunoassay
• Reference Values