Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets.

Abstract

The capacity of serotoninergic drugs to selectively suppress carbohydrate (CHO) intake was investigated using a procedure sensitive to drug action. The drug d-fenfluramine was administered chronically to rats whose weight had been increased by exposure to either a fat or CHO-supplemented hyperphagia-inducing diet. The drug exerted a more potent anorexic effect and weight-reducing action in rats given the dietary supplements than in control chow-fed rats. Tolerance to the drug was not apparent even after 40 days of treatment. However, there was no evidence for a selective inhibition of CHO intake, nor was the drug more potent with the CHO-supplemented diet. d-Fenfluramine was equally effective against the hyperphagia and weight gain induced by either fat or CHO supplements.

• Authors: J E Blundell, A J Hill
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 31 Issue 4 Pg. 773-8 (Dec 1988) ISSN: 0091-3057 [Print] United States
• PMID: 3252267 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Carbohydrates
• Dietary Fats
• Fenfluramine

Topics

• Animals
• Body Weight (drug effects)
• Diet
• Dietary Carbohydrates (administration & dosage)
• Dietary Fats (administration & dosage)
• Drinking Behavior (drug effects)
• Energy Intake (drug effects)
• Feeding Behavior (drug effects)
• Female
• Fenfluramine (pharmacology)
• Rats