Efficacy of 15-(123I)-p-iodophenyl pentadecanoic acid (IPPA) in assessing myocardial metabolism in a model of reversible global ischemia.

Abstract

In a canine model of reversible global ischemia, the residual quantity of 123I was assessed following a bolus injection of 15-p-(123I)-iodophenyl pentadecanoic acid (123I-IPPA). This technique was used to assess changes in free fatty acid metabolism following the utilization of three cardioplegic formulations. Cardioplegic arrest was initiated with Tyers' iso-osmolar (IO) solution (Group A); IO + superoxide dismutase (SOD) (Group B) and IO + allopurinol (Group C). Pre and post operative scanning were completed with 2-5 mCi 123I-IPPA. Clearance was assessed by IPPA time activity curve analysis generating t1/2 (half lives in min) for the early and late phases of the curve. The assessment between groups demonstrated that the elimination of 123I-IPPA products (early phase) was faster from the lateral wall in groups B and C versus group A (14 +/- 12 min, 13 +/- 9 min and 24 +/- 10 min, respectively). The elimination of IPPA (late phase) was also faster from the lateral wall in groups B and C when compared to group A (240 +/- 270 min, 132 +/- 85 min and 416 +/- 238 min). Examining the changes between control and postoperative values for each area of the left ventricle within each group demonstrated no significant changes for groups B and C. Group A, however, demonstrated significantly increased t1/2 values for the lateral wall (early and late phases) and the apical wall (late phase).(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: M P Hudon, D M Lyster, E W Jamieson, K A Qayumi, M C Kiess, L J Rosado, A P Autor, C Sartori, H Dougan, J van den Broek
• Journal: European journal of nuclear medicine (Eur J Nucl Med) Vol. 14 Issue 12 Pg. 594-9 ( 1988) ISSN: 0340-6997 [Print] Germany
• PMID: 3243307 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cardioplegic Solutions
• Iodine Radioisotopes
• Iodobenzenes
• omega-(4-iodophenyl)pentadecanoic acid

Topics

• Animals
• Cardioplegic Solutions (pharmacology)
• Coronary Disease (diagnostic imaging, metabolism)
• Dogs
• Heart (diagnostic imaging)
• Heart Arrest, Induced
• Iodine Radioisotopes
• Iodobenzenes
• Myocardium (metabolism)
• Radionuclide Imaging