[Changes in organ-specific enzymes under the influence of an enriched food ration in experimental cadmium poisoning].

Abstract

During a 3-month experiment is studied the effect of enriched with iron, calcium, phosphorous and vitamin D2 food ration on the changes in the organospecific enzymes in everyday introduction in the organism of experimental animals of cadmium sulfate in dose 1/40 LD50 (7 mg/kg-1). The serum activity of GOT and GPT is traced in dynamics at the end of the first, second and third month, as well as the activity of gamma-GT, LAP and APh in homogenates of liver and kidneys. The changes established in most of the experimental groups and the dates of observation show an increase in the serum and tissue activity of the examined enzymes (GOT, GPT, LAP). The tissue activity of gamma-GT and the quantity of free sulfhydryl groups are decreased in some of the dates of observation (I and III month). Both the isolated effect of cadmium and enriched food ration and their combined effect are discussed.

• Authors: M Koleva, T Kuneva, P Boiadzhieva
• Journal: Problemi na khigienata (Probl Khig) Vol. 13 Pg. 124-9 ( 1988) ISSN: 0323-9179 [Print] Bulgaria
• Vernacular Title: Promeni v niakoi organospetsifichni enzimi pod vliianie na obogatena khranitelna dazhba pri eksperimentalna kadmieva intoksikatsiia.
• PMID: 3241792 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Sulfhydryl Compounds

Topics

• Animals
• Cadmium Poisoning (diet therapy, enzymology)
• Food, Fortified
• Kidney (drug effects, enzymology)
• Liver (drug effects, enzymology)
• Male
• Rats
• Rats, Inbred Strains
• Sulfhydryl Compounds (metabolism)
• Time Factors