[Constitutional dysfunction of heparin cofactor II with a tendency for venous thrombosis].

Abstract

Simultaneous determination of heparin cofactor II (HC II) immunologically as antigen (HC II:Ag) and functionally as heparin cofactor (H-HC II) and as dermatan sulfate cofactor (DS-HC II) renders possible a distinction between quantitative and qualitative deficiencies. The usefulness of these methods is demonstrated in the light of a family with several heterozygotes of quantitative HC II deficiency and two unrelated heterozygote men with defective dermatan sulfate cofactor function (DS HC II) and normal HC II:Ag and H-HC II.

• Authors: G A Marbet, B Zbinden, F Duckert
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 118 Issue 43 Pg. 1586-8 (Oct 29 1988) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Konstitutionelle Dysfunktion von Heparin-Kofaktor II mit venöser Thromboseneigung.
• PMID: 3238395 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antithrombins
• Glycoproteins
• Dermatan Sulfate
• Heparin Cofactor II

Topics

• Adolescent
• Adult
• Antithrombins (physiology)
• Dermatan Sulfate (blood)
• Female
• Glycoproteins (deficiency, physiology)
• Heparin Cofactor II
• Humans
• Male
• Middle Aged
• Pulmonary Embolism (physiopathology)
• Thrombophlebitis (genetics, physiopathology)