Abstract |
A case of Kleine-Levin syndrome with true hypersomnia and a case of sub-wakefulness are described. In both patients lumbar cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol levels have been assayed during episodes of hypersomnia and normal sleep-waking cycles. Besides an increased 5-hydroxytryptamine turnover, mainly an increased dopamine turnover has been detected in both kinds of hypersomnia, and this finding was more remarkable in the case with sub-wakefulness. The probable role of dopamine in abnormalities in the sleep-waking cycle is discussed on the basis of results in experimental animal hypersomnias.
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Authors | P Livrea, F M Puca, A Barnaba, L Di Reda |
Journal | European neurology
(Eur Neurol)
Vol. 15
Issue 2
Pg. 71-6
( 1977)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 323018
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Catechols
- Phenylacetates
- 3-Methoxy-4-hydroxyphenylethanol
- Serotonin
- Hydroxyindoleacetic Acid
- Probenecid
- Dopamine
- Homovanillic Acid
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Topics |
- 3-Methoxy-4-hydroxyphenylethanol
(cerebrospinal fluid)
- Adolescent
- Catechols
(cerebrospinal fluid)
- Child
- Disorders of Excessive Somnolence
(cerebrospinal fluid)
- Dopamine
(cerebrospinal fluid)
- Feeding and Eating Disorders
(cerebrospinal fluid)
- Female
- Homovanillic Acid
(cerebrospinal fluid)
- Humans
- Hydroxyindoleacetic Acid
(cerebrospinal fluid)
- Male
- Phenylacetates
(cerebrospinal fluid)
- Probenecid
- Serotonin
(cerebrospinal fluid)
- Sleep Wake Disorders
(cerebrospinal fluid)
- Syndrome
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