HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Abnormal central monoamine metabolism in humans with "true hypersomnia" and "sub-wakefulness".

Abstract
A case of Kleine-Levin syndrome with true hypersomnia and a case of sub-wakefulness are described. In both patients lumbar cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol levels have been assayed during episodes of hypersomnia and normal sleep-waking cycles. Besides an increased 5-hydroxytryptamine turnover, mainly an increased dopamine turnover has been detected in both kinds of hypersomnia, and this finding was more remarkable in the case with sub-wakefulness. The probable role of dopamine in abnormalities in the sleep-waking cycle is discussed on the basis of results in experimental animal hypersomnias.
AuthorsP Livrea, F M Puca, A Barnaba, L Di Reda
JournalEuropean neurology (Eur Neurol) Vol. 15 Issue 2 Pg. 71-6 ( 1977) ISSN: 0014-3022 [Print] Switzerland
PMID323018 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Catechols
  • Phenylacetates
  • 3-Methoxy-4-hydroxyphenylethanol
  • Serotonin
  • Hydroxyindoleacetic Acid
  • Probenecid
  • Dopamine
  • Homovanillic Acid
Topics
  • 3-Methoxy-4-hydroxyphenylethanol (cerebrospinal fluid)
  • Adolescent
  • Catechols (cerebrospinal fluid)
  • Child
  • Disorders of Excessive Somnolence (cerebrospinal fluid)
  • Dopamine (cerebrospinal fluid)
  • Feeding and Eating Disorders (cerebrospinal fluid)
  • Female
  • Homovanillic Acid (cerebrospinal fluid)
  • Humans
  • Hydroxyindoleacetic Acid (cerebrospinal fluid)
  • Male
  • Phenylacetates (cerebrospinal fluid)
  • Probenecid
  • Serotonin (cerebrospinal fluid)
  • Sleep Wake Disorders (cerebrospinal fluid)
  • Syndrome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: