Abstract |
Olsalazine is a new drug for the treatment of ulcerative and Crohn's colitis. The toxicological, pharmacological and pharmacokinetic profiles of olsalazine are excellent; the only side-effect noted from clinical trials with olsalazine is an increased incidence of loose stools and occasional diarrhoea. At high olsalazine concentrations, a direct effect on the net water absorption of the intestine is apparent. This effect is not due to a decrease in absorption, but to an induction of a rapidly reversible, Cl- dependent water secretion. In rats experimentally subjected to olsalazine induced diarrhoea (150 mg/kg), a total adaptation occurs within 3-4 days. This adaptation is not due to tachyphylaxis, but to an increased absorption capacity in the colon and caecum. Similar adaptation has been noted in other species including man.
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Authors | T Berglindh, E Landström, E Bergqvist |
Journal | Scandinavian journal of gastroenterology. Supplement
(Scand J Gastroenterol Suppl)
Vol. 148
Pg. 24-8
( 1988)
ISSN: 0085-5928 [Print] England |
PMID | 3227308
(Publication Type: Journal Article)
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Chemical References |
- Aminosalicylic Acids
- olsalazine
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Topics |
- Adaptation, Physiological
- Aminosalicylic Acids
(therapeutic use, toxicity)
- Animals
- Diarrhea
(chemically induced)
- Humans
- Intestinal Absorption
(drug effects)
- Rats
- Water-Electrolyte Balance
(drug effects)
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