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Induction of and adaptation to olsalazine induced intestinal volume load.

Abstract
Olsalazine is a new drug for the treatment of ulcerative and Crohn's colitis. The toxicological, pharmacological and pharmacokinetic profiles of olsalazine are excellent; the only side-effect noted from clinical trials with olsalazine is an increased incidence of loose stools and occasional diarrhoea. At high olsalazine concentrations, a direct effect on the net water absorption of the intestine is apparent. This effect is not due to a decrease in absorption, but to an induction of a rapidly reversible, Cl- dependent water secretion. In rats experimentally subjected to olsalazine induced diarrhoea (150 mg/kg), a total adaptation occurs within 3-4 days. This adaptation is not due to tachyphylaxis, but to an increased absorption capacity in the colon and caecum. Similar adaptation has been noted in other species including man.
AuthorsT Berglindh, E Landström, E Bergqvist
JournalScandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 148 Pg. 24-8 ( 1988) ISSN: 0085-5928 [Print] England
PMID3227308 (Publication Type: Journal Article)
Chemical References
  • Aminosalicylic Acids
  • olsalazine
Topics
  • Adaptation, Physiological
  • Aminosalicylic Acids (therapeutic use, toxicity)
  • Animals
  • Diarrhea (chemically induced)
  • Humans
  • Intestinal Absorption (drug effects)
  • Rats
  • Water-Electrolyte Balance (drug effects)

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