A model of atrial ectopic tachycardia in the rat. - <a href="../public/authorSummary-Tribble, J.do">J Tribble</a>, <a href="../public/authorSummary-Weinhouse, E.do">E Weinhouse</a>, <a href="../public/authorSummary-Jarenwattananon, M.do">M Jarenwattananon</a>, <a href="../public/authorSummary-Nudel, D B.do">D B Nudel</a> | CureHunter

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A model of atrial ectopic tachycardia in the rat.

Abstract	A model of atrial ectopic tachycardia (AET) in the adult rat is described. Pentobarbital-anesthetized adult male rats given digoxin 30 mg/kg s.c. develop AET 50 min after administration. Heart rate and rhythm were determined by electrocardiography using limb leads, I, II and III. This model of AET is simple, sustained and economical. As a supplement to models of ventricular arrhythmias, this model might broaden the pre-clinical evaluation of antiarrhythmic agents.
Authors	J Tribble, E Weinhouse, M Jarenwattananon, D B Nudel
Journal	Methods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 10 Issue 8 Pg. 521-6 (Aug 1988) ISSN: 0379-0355 [Print] Spain
PMID	3226220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Digoxin
Topics	Animals Digoxin (pharmacology) Disease Models, Animal Electrocardiography Male Rats Rats, Inbred Strains Tachycardia, Ectopic Atrial (physiopathology) Tachycardia, Supraventricular (physiopathology)

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