[Dose-response curve and preliminary clinical study of a laxative, lactilol].

Abstract

15 women complaining of chronic constipation were included in a prospective open trial to determine the laxative action and minimal effective dose of lactitol. Through the administration of increasing doses, an ED50 of 0.25 g/kg/day, was established. During a 15-day treatment period at the minimal effective dose, all patients had reduced symptoms of constipation as compared with a previous 15-day control period. Side effects of minor intensity were frequently recorded (flatulence, rumblings, wind, and, less frequently, abdominal cramps or nausea). Thus, the use of lactitol for symptomatic treatment of constipation deserves further clinical studies to determine better its indications and benefit.

• Authors: M Walder, T Buclin, J Biollaz, M E Kitler, J L Schelling
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 118 Issue 50 Pg. 1925-7 (Dec 17 1988) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Courbe dose-réponse et étude clinique préliminaire d'un laxatif, le lactitol.
• PMID: 3222688 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cathartics
• Sugar Alcohols
• lactitol

Topics

• Adult
• Cathartics (adverse effects, therapeutic use)
• Constipation (drug therapy)
• Dose-Response Relationship, Drug
• Female
• Humans
• Middle Aged
• Sugar Alcohols (administration & dosage, adverse effects, therapeutic use)