Regional changes in brain histamine levels following dietary-induced thiamine deficiency in rats.

Abstract

Histamine levels in thiamine deficient rats were significantly lower in the hippocampus, amygdala, olfactory bulb, thalamus and pons-medulla oblongata than those of normal and pair-fed groups. In the case of the hypothalamus, thiamine deficiency produced a significant increase in histamine levels. These changes observed in the thiamine deficient group were reversed to the normal levels by supplying the normal diet. These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.

• Authors: K Onodera, K Maeyama, T Watanabe
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 47 Issue 3 Pg. 323-6 (Jul 1988) ISSN: 0021-5198 [Print] Japan
• PMID: 3221531 (Publication Type: Journal Article)

Chemical References

• Histamine

Topics

• Animals
• Brain (metabolism)
• Diet
• Histamine (metabolism)
• Male
• Mast Cells (metabolism)
• Neurons (metabolism)
• Rats
• Rats, Inbred Strains
• Thiamine Deficiency (metabolism)