Pyoderma gangrenosum in acute myeloid leukaemia during immunosuppression.

Abstract

We describe a patient who developed pyoderma gangrenosum during the remission phase of acute myeloid leukaemia whilst receiving maintenance therapy with methotrexate and 6-mercaptopurine. The spontaneous resolution of these skin lesions following discontinuation of chemotherapy suggests that these drugs may be of major significance in the aetiology of pyoderma gangrenosum. Nevertheless, 27 months later, a relapse of the leukaemia followed. Although pyoderma gangrenosum occurred during clinical remission, we cannot rule out a synergism of leukaemia and chemotherapy in its pathogenesis.

• Authors: P C van de Kerkhof, G A de Vaan, R Holland
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 148 Issue 1 Pg. 34-6 (Oct 1988) ISSN: 0340-6199 [Print] Germany
• PMID: 3197731 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mercaptopurine
• Methotrexate

Topics

• Adult
• Gangrene (etiology)
• Humans
• Immunosuppression Therapy (adverse effects)
• Leukemia, Myeloid (drug therapy)
• Male
• Mercaptopurine (adverse effects)
• Methotrexate (adverse effects)
• Pyoderma (etiology)