Abstract |
The salivary concentration of 17-hydroxyprogesterone (17-OHP) was determined in 11 patients (aged 6 months to 13 years) with congenital adrenogenital syndrome (AGS) due to C21-hydroxylase deficiency and six healthy controls, in order to assess its value in monitoring treatment of AGS. Salivary 17-OHP was measured by a specific radioimmunoassay after extraction with dichloromethane. Only 100 microliters of saliva was needed for the assay. There was a good correlation (r = 0.93; P less than 0.01) between 17-OHP concentrations in paired saliva and serum samples from the patients and the control subjects. There was a wide scatter in salivary 17-OHP levels in the range between 164 ng/l (1.7 ng/ml in serum) of satisfactorily or overtreated patients and 15,500 ng/l (247 ng/l in serum) of undertreated patients. Levels in normal children were between 200 and 300 ng/l. It is concluded that treatment of congenital AGS (21-hydroxylase deficiency) can be carefully monitored in children with the noninvasive, frequently repeatable measurement of salivary 17-OHP.
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Authors | O Arisaka, N Shimura, Y Nakayama, M Arisaka, K Yabuta |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 113
Issue 49
Pg. 1913-5
(Dec 09 1988)
ISSN: 0012-0472 [Print] Germany |
Vernacular Title | Speichel-17-Hydroxyprogesteron-Konzentration zur Therapieüberwachung bei angeborener Nebennierenhyperplasie. |
PMID | 3197614
(Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxyprogesterones
- 17-alpha-Hydroxyprogesterone
- Fludrocortisone
- Hydrocortisone
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Topics |
- 17-alpha-Hydroxyprogesterone
- Adolescent
- Adrenal Hyperplasia, Congenital
(blood, diagnosis, drug therapy)
- Child
- Child, Preschool
- Female
- Fludrocortisone
(therapeutic use)
- Humans
- Hydrocortisone
(therapeutic use)
- Hydroxyprogesterones
(analysis, blood)
- Infant
- Male
- Monitoring, Physiologic
- Radioimmunoassay
- Saliva
(analysis)
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