Direct correlation between calcium content and blood pressure: a study of aortic coarctation in rats.

Abstract

The calcium content of aorta was measured by atomic absorption after coarctation in the rat. At 7 and 14 days, the calcium content was elevated on the proximal side of the coarctation, where pressure was increased significantly. On the distal, low pressure side of the aortic coarctation, calcium was reduced significantly. There is a direct correlation between the blood pressure and the content of calcium (r = 0.69, P less than 0.001). The width of the aortic media on the high pressure side was increased significantly at 7 and 14 days after coarctation, whereas no significant changes in width were present on the low pressure side of the constriction. We conclude that pressure regulates the aortic calcium content, likely acting through a local effect.

• Authors: F Yang, P A Nickerson
• Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (Proc Soc Exp Biol Med) Vol. 189 Issue 2 Pg. 206-10 (Nov 1988) ISSN: 0037-9727 [Print] United States
• PMID: 3194434 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Calcium

Topics

• Animals
• Aorta (analysis, pathology)
• Aortic Coarctation (metabolism, pathology, physiopathology)
• Blood Pressure
• Body Weight
• Calcium (analysis)
• Female
• Organ Size
• Rats