Rapid production of pancreatic carcinoma by initiation with N-nitroso-bis(2-oxopropyl)amine and repeated augmentation pressure in hamsters.

Abstract

A rapid-production model incorporating the principle of selection by resistance to cytotoxicity demonstrated earlier for liver carcinogenesis in rats was established for pancreatic carcinoma development in Syrian hamsters. Adenocarcinomas were induced in 84% of treated animals by 10 weeks after initiation with 70 mg of N-nitroso-bis(2-oxopropyl)amine (BOP) per kg of body weight when augmentation pressure (choline-deficient diet combined with DL-ethionine and L-methionine and administration of 20 mg/kg BOP upon return to basal diet) was applied three times. A 52% yield of cholangiocellular tumors also resulted from this experimental protocol.

• Authors: K Mizumoto, M Tsutsumi, A Denda, Y Konishi
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 80 Issue 19 Pg. 1564-7 (Dec 07 1988) ISSN: 0027-8874 [Print] United States
• PMID: 3193471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Nitrosamines
• nitrosobis(2-oxopropyl)amine
• Methionine
• Ethionine

Topics

• Animals
• Carcinogens
• Carcinoma (etiology)
• Choline Deficiency (complications)
• Cocarcinogenesis
• Cricetinae
• Diet
• Ethionine (administration & dosage)
• Female
• Liver (drug effects)
• Mesocricetus
• Methionine (administration & dosage)
• Nitrosamines (toxicity)
• Pancreatic Neoplasms (etiology)