Abstract |
The pharmacokinetics of the quinolone lomefloxacin were determined following a single 400-mg oral dose given to each of six male volunteers. Concentrations in serum, urine, and cantharidin-induced inflammatory fluid were determined by a microbiological assay. Samples from two volunteers were also assayed by high-performance liquid chromatography. The mean peak level in serum, 4.7 micrograms/ml, was attained within 1 h of administration. The mean elimination half-life from serum was 7 h. Inflammatory fluid was penetrated rapidly, with a mean peak level of 3.5 micrograms/ml occurring after 2.7 h. The mean recovery of lomefloxacin from urine over 48 h was 76% of the administered dose. There was a minor peak on the high-performance liquid chromatography trace, suggesting a small amount of unidentified metabolite. This was present only in urine; no detectable metabolites were found in serum. This study suggests that either once-daily or twice-daily dosage of lomefloxacin should be sufficient to treat urinary or systemic infections, respectively, caused by susceptible pathogens.
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Authors | J W Stone, J M Andrews, J P Ashby, D Griggs, R Wise |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 32
Issue 10
Pg. 1508-10
(Oct 1988)
ISSN: 0066-4804 [Print] United States |
PMID | 3190181
(Publication Type: Journal Article)
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Chemical References |
- 4-Quinolones
- Anti-Infective Agents
- Fluoroquinolones
- Quinolones
- lomefloxacin
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Topics |
- 4-Quinolones
- Administration, Oral
- Adult
- Anti-Infective Agents
(administration & dosage, pharmacokinetics)
- Body Fluids
(analysis)
- Chromatography, High Pressure Liquid
- Fluoroquinolones
- Half-Life
- Humans
- Male
- Quinolones
- Urinary Tract Infections
(drug therapy)
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