Abstract | STUDY OBJECTIVE: To determine the effect of zidovudine on platelet counts in patients with human immunodeficiency virus (HIV)-associated thrombocytopenia. DESIGN: The study was prospective, controlled, and blinded. Each patient received active drug and placebo. Platelet counts were compared before and after receiving zidovudine. SETTING: Outpatient clinics in Geneva, Lausanne, and Zürich, Switzerland. PATIENTS: Sequential sample of ten patients (five intravenous drug addicts, four homosexual men, one Zairian) who were seropositive for HIV, and had platelet counts between 20 and 100 X 10(9)/L (20,000 to 100,000/mm3). Patients with the acquired immunodeficiency syndrome ( AIDS) were not enrolled. None had been previously treated for thrombocytopenia, and no medication except zidovudine or placebo was administered during the trial period. INTERVENTIONS: Five patients received 8 weeks of zidovudine (2 g/d for 2 weeks, and 1 g/d for 6 weeks), followed by 8 weeks of placebo. The other five patients received placebo for 8 weeks followed by zidovudine. MEASUREMENTS AND MAIN RESULTS: Platelet counts increased in each patient while on zidovudine, but not while on placebo; the mean increase was 54.6 X 10(9)/L +/- 11.25 (SE) from 53.2 to 107.8 X 10(9)/L (P less than 0.004). After the end of zidovudine treatment, platelet counts remained elevated for more than 4 weeks in three of five patients. One patient developed granulocytopenia and anemia during treatment with zidovudine. CONCLUSIONS:
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Authors | |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 109
Issue 9
Pg. 718-21
(Nov 01 1988)
ISSN: 0003-4819 [Print] United States |
PMID | 3190058
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Anemia
(chemically induced)
- Double-Blind Method
- Female
- HIV Seropositivity
(complications)
- Humans
- Male
- Middle Aged
- Neutropenia
(chemically induced)
- Prospective Studies
- Thrombocytopenia
(drug therapy, etiology)
- Zidovudine
(adverse effects, therapeutic use)
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