Effects of estrogen-induced hyperlipidemia on the erythrocyte membrane in chicks.

Abstract

The effects of estrogen-induced hyperlipidemia on plasma lipid peroxidation, fatty acid composition and osmotic fragility of erythrocytes in chickens were studied. Young male chickens implanted with estrogen for three wk developed a marked hyperlipidemia. Plasma levels of triglyceride, cholesterol and phospholipid were elevated 68-, four- and 24-fold, respectively, over controls. There was also a two-fold increase in plasma lipid peroxidation measured by the thiobarbituric acid test. Vitamin E supplement (1,000 IU/kg diet) reduced the plasma lipid peroxidation to the control level, but had no effect on the plasma lipid content. Estrogen-induced hyperlipidemia resulted in changes in the fatty acid composition of membrane lipids of erythrocytes. The major changes were an increase in oleic acid from 10.0% to 14.2% and a decrease in linoleic acid from 31.3% to 26.0%. The erythrocytes with an altered membrane fatty acid composition were found to have an increased osmotic fragility. It was apparent that there was a direct correlation between the oleic acid content and the osmotic fragility of erythrocytes.

• Authors: B H Cho, T L Smith, J R Park, F A Kummerow
• Journal: Lipids (Lipids) Vol. 23 Issue 9 Pg. 853-6 (Sep 1988) ISSN: 0024-4201 [Print] United States
• PMID: 3185119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrogens
• Fatty Acids
• Lipid Peroxides
• Membrane Lipids

Topics

• Animals
• Chickens
• Erythrocyte Membrane (analysis)
• Estrogens (pharmacology)
• Fatty Acids (blood)
• Hemolysis
• Hyperlipidemias (blood, chemically induced)
• Lipid Peroxides (blood)
• Male
• Membrane Lipids (analysis)
• Osmotic Fragility