Abstract |
Twelve hospitalised patients, affected by biliary tract infections, were treated with cefotetan at dosages ranging between 4 and 6 g daily i.v. In only 11 patients was the aetiological agent identified. Eleven patients (91.67%) completely recovered from their infections and the pathogens were eradicated; the treatment failed in only 1 patient (8.33%). Furthermore, determinations were made of cefotetan concentrations in serum, gallbladder bile, gallbladder wall and gallstones of 14 patients undergoing cholecystectomy: in 7 patients after only 1 injection i.v. of 2 g and in 7 patients after 7 injections i.v. of 2 g at intervals of 12 h. The levels recorded were several times higher than the minimum inhibitory concentrations against bacteria that are most often responsible for biliary infections. Cefotetan is a promising and effective antimicrobial agent in the therapy of biliary tract infections.
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Authors | P Cristiano, R Lobello, M R Iovene, G De Ascentis, P Altucci, F Paradisi, L Manguso |
Journal | Chemioterapia : international journal of the Mediterranean Society of Chemotherapy
(Chemioterapia)
Vol. 7
Issue 4
Pg. 233-6
(Aug 1988)
ISSN: 0392-906X [Print] Italy |
PMID | 3180302
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Bacterial Infections
(drug therapy)
- Biliary Tract Diseases
(drug therapy)
- Cefotetan
(pharmacokinetics, therapeutic use)
- Cholecystectomy
- Female
- Humans
- Injections, Intravenous
- Male
- Middle Aged
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