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Critical temperatures for the interaction of free fatty acids with the erythrocyte membrane.

Abstract
Non-esterified long-chain fatty acids reduce the extent of hypotonic hemolysis at a certain low concentration range but cause hemolysis at higher concentrations. This biphasic behavior was investigated at different temperatures (0-37 degrees C) for lauric (12:0), myristic (14:0), palmitoleic (16:1), oleic (cis-18:1) and elaidic (trans-18:1) acids. The results are summarized as follows: (A) the fatty acids examined exhibit a high degree of specificity in their thermotropic behavior; (B) oleic acid protects against hypotonic hemolysis even at the highest concentrations, up to 15 degrees C, when it becomes hemolytic, but only in a limited concentration range; (C) elaidic acid does not affect the osmotic stability of erythrocytes up to 20 degrees C, when it starts protecting: above 30 degrees C, it becomes hemolytic at the highest concentrations; (D) palmitoleic acid is an excellent protecting agent at all temperatures in a certain concentration range, becoming hemolytic at higher concentrations; (E) lauric acid protects up to 30 degrees C and becomes hemolytic only above this temperature; (F) myristic acid exhibits an extremely unusual behavior at 30 and 37 degrees C by having alternating concentration ranges of protecting and hemolytic effects; (G) there is a common critical temperature for hemolysis at 30 degrees C for saturated and trans-unsaturated fatty acids; (H) the initial slope of Arrhenius plots of percent hemolysis at the concentration of maximum protection is negative for cis-unsaturated fatty acids and positive for saturated and trans-unsaturated fatty acids.
AuthorsA Csordas, M Rybczynska
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 944 Issue 2 Pg. 155-63 (Oct 06 1988) ISSN: 0006-3002 [Print] Netherlands
PMID3179287 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fatty Acids, Nonesterified
  • Lauric Acids
  • Myristic Acids
  • Oleic Acids
  • Palmitic Acids
  • Myristic Acid
  • lauric acid
  • Oleic Acid
  • Palmitic Acid
  • elaidic acid
Topics
  • Erythrocyte Membrane (metabolism)
  • Fatty Acids, Nonesterified (blood)
  • Humans
  • Lauric Acids (blood)
  • Myristic Acid
  • Myristic Acids (blood)
  • Oleic Acid
  • Oleic Acids (blood)
  • Osmotic Fragility
  • Palmitic Acid
  • Palmitic Acids (blood)
  • Temperature

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