Premature rupture of fetal membranes changes in collagen type.

Abstract

Collagen from the chorioamnion units from premature and term pregnancies was solubilized by limited pepsin digestion and subjected to SDS-PAG electrophoresis. Collagen types were quantitated by densitometry. It was found that collagen type III decreases and collagen type V tends to increase as gestational age advances. Investigating the relative abundance of collagen types at various membrane sites from term pregnancies revealed that type V decreases in the amnion as the rupture site is approached. It is concluded that since type V collagen is more resistant to collagenases, its decrease may predispose that particular site to rupture.

• Authors: N S al-Zaid, K A Gumaa, M N Bou-Resli, M E Ibrahim
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 67 Issue 4 Pg. 291-5 ( 1988) ISSN: 0001-6349 [Print] United States
• PMID: 3176950 (Publication Type: Journal Article)

Chemical References

• Collagen

Topics

• Amnion (metabolism)
• Chorion (metabolism)
• Collagen (metabolism)
• Densitometry
• Electrophoresis, Polyacrylamide Gel
• Female
• Fetal Membranes, Premature Rupture (metabolism)
• Humans
• Pregnancy