Incidence of renal complications in Schönlein-Henoch purpura syndrome in dependence of an early administration of steroids.

Abstract

Between 1976 and 1986, the authors treated 33 children with Schönlein-Henoch purpura (S-H purpura), with physiological urinary finding on admission. Twenty-three of them received prednisone already at the beginning of hospitalization, 10 were not given any prednisone at all. In patients with prednisone, nephropathy occurred only once (4.3%), in those without prednisone it occurred 5 times (50%), the incidence being thus significantly higher. Prednisone was administered in doses ranging between 1.0 and 2.5 mg/kg body mass/day, on an average for 21 days (first 10 days in the same dose, later in reduced doses). Since there is a general lack of data on the positive effect of steroids upon the prevention of nephropathies in S-H purpura, the authors recommend more thorough studies in the initial stage of the disease (before the development of nephropathies).

• Authors: J Buchanec, V Galanda, S Beláková, M Minárik, M Zibolen
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 20 Issue 4 Pg. 409-12 ( 1988) ISSN: 0301-1623 [Print] Netherlands
• PMID: 3170111 (Publication Type: Journal Article)

Chemical References

• Prednisone

Topics

• Child
• Child, Preschool
• Humans
• IgA Vasculitis (complications, drug therapy)
• Kidney Diseases (etiology, prevention & control)
• Prednisone (therapeutic use)
• Retrospective Studies