Abstract |
The effect of the protease inhibitor, aprotinin, was examined in rats during traumatic shock. In sham-operated control rats, intravenous administration of aprotinin (20,000 or 40,000 KIU/kg) showed no immediate changes in the mean arterial blood pressure and heart rate. In rats subjected to Noble-Collip drum trauma, aprotinin at a dose of 20,000 KIU/kg prolonged survival time to 2.1 +/- 0.3 hr (p less than 0.05) and 40,000 KIU/kg prolonged the survival time of rats to a greater extent (3.1 +/- 0.4 hr, p less than 0.001) compared to rats given only its vehicle (1.1 +/- 0.2 hr, mean +/- SE). The improved survival was accompanied by inhibition of the plasma accumulation of the cardiotoxic peptide, myocardial depressant factor ( MDF). However, aprotinin showed no inhibitory effect on the plasma accumulation of the lysosomal enzyme, cathepsin D. Aprotinin has a beneficial effect on traumatic shock in rats possibly by its potent inhibitory action on MDF formation.
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Authors | H Araki, A M Lefer |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
Vol. 241
Issue 2
Pg. 316-23
(Oct 1979)
ISSN: 0003-9780 [Print] Belgium |
PMID | 316692
(Publication Type: Journal Article)
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Chemical References |
- Myocardial Depressant Factor
- Protease Inhibitors
- Aprotinin
- Cathepsins
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Topics |
- Animals
- Aprotinin
(pharmacology)
- Blood Pressure
(drug effects)
- Cathepsins
(metabolism)
- Lysosomes
(enzymology)
- Male
- Myocardial Depressant Factor
(metabolism)
- Protease Inhibitors
- Rats
- Shock, Traumatic
(metabolism, physiopathology)
- Time Factors
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