Esterase D: evaluation of a potential derived gene marker for hereditary retinoblastoma.
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| Abstract |
The gene locus of esterase D is closely linked to that coding for retinoblastoma. When the occurrence of retinoblastoma is based on a chromosome deletion, red cell esterase D might be a potential tumor marker for diagnosing retinoblastoma. This diagnostic utility was tested by measuring total esterase D and differentiating esterase D to its different phenotypes in red cells of patients with bilateral retinoblastoma, unilateral retinoblastoma having a positive family history and unilateral sporadic retinoblastoma. These results are compared with the findings within a group of first degree relatives of these patients and of a reference group of apparently healthy controls. A poor sensitivity and a low positive predictive value were found. So, the conclusion might be drawn that screening of all retinoblastoma patients for esterase D in order to get insight in the weighting of risk of retinoblastoma is very much open to question and due to high cost efficiency ratio might not be recommended.
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| Authors | C van der Heiden, A F Geurtzen, W Brink, J B de Klerk, F A Beemer |
| Journal | Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 173 Issue 1 Pg. 81-7 (Mar 31 1988) ISSN: 0009-8981 [Print] Netherlands |
| PMID | 3164261 (Publication Type: Journal Article) |
| Chemical References |
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