Experimental infections of the musculoskeletal system: evaluation with MR imaging and Tc-99m MDP and Ga-67 scintigraphy.

Abstract

Acute osteomyelitis, soft-tissue infection, or both were experimentally produced in 38 New Zealand white rabbits, and three-phase technetium-99m methylene diphosphonate, gallium-67, and magnetic resonance (MR) images were obtained 7 or 14 days after infection. There was no significant difference between radionuclide studies and MR images in the detection of osteomyelitis, but MR imaging was significantly more sensitive (100% vs. 69%; P less than .01) in the detection of soft-tissue infection. In addition, cellulitis could not be distinguished from soft-tissue abscess on radionuclide studies, whereas MR imaging was 92% accurate in depicting soft-tissue abscesses. Further research is necessary to determine how to relate these findings to true human clinical situations.

• Authors: J Beltran, R B McGhee, P B Shaffer, J O Olsen, W F Bennett, T R Foster, M S McCalla, L A Iskra, R L Blagg, D S Biller
• Journal: Radiology (Radiology) Vol. 167 Issue 1 Pg. 167-72 (Apr 1988) ISSN: 0033-8419 [Print] United States
• PMID: 3162326 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Gallium Radioisotopes
• Technetium Tc 99m Medronate

Topics

• Abscess (diagnosis)
• Animals
• Cellulitis (diagnosis)
• Gallium Radioisotopes
• Magnetic Resonance Imaging
• Osteomyelitis (diagnosis)
• Rabbits
• Staphylococcal Infections (diagnosis)
• Technetium Tc 99m Medronate
• Tomography, X-Ray Computed